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Low cerebral blood flow velocity and risk of white matter hyperintensities
Author(s) -
Tzourio Christophe,
Lévy Claude,
Dufouil Carole,
Touboul PierreJean,
Ducimetière Pierre,
Alpérovitch Annick
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.82
Subject(s) - hyperintensity , cerebral blood flow , cardiology , medicine , quartile , transcranial doppler , magnetic resonance imaging , blood flow , odds ratio , psychology , radiology , confidence interval
Cerebral blood flow velocity (CBF‐V) measured by transcranial doppler was assessed in 628 elderly individuals who had cerebral magnetic resonance imaging performed as part of a population‐based study on vascular aging. Cerebral white matter hyperintensities (WMHs) were associated with low CBF‐V, such as the adjusted odds ratios of severe WMHs from highest (referent) to lowest quartile of mean CBF‐V were 1.0, 1.7, 3.7, and 4.3 ( p = 0.001). Further, CBF‐V was found to be a stronger risk factor for WMHs than high blood pressure. These findings suggest that the assessment of CBF‐V might be a powerful tool in future studies on WMHs. Ann Neurol 2001;49:411–414