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Children with comorbid attention‐deficit‐hyperactivity disorder and tic disorder: Evidence for additive inhibitory deficits within the motor system
Author(s) -
Moll Gunther H.,
Heinrich Hartmut,
Trott GötzErik,
Wirth Sigrun,
Bock Nathalie,
Rothenberger Aribert
Publication year - 2001
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.77
Subject(s) - transcranial magnetic stimulation , silent period , attention deficit hyperactivity disorder , comorbidity , psychology , neurophysiology , tics , neuroscience , inhibitory postsynaptic potential , tic disorder , audiology , psychiatry , stimulation , medicine
Abstract For children with attention‐deficit‐hyperactivity disorder (ADHD) or tic disorder (TD), we recently reported deficient inhibitory mechanisms within the motor system by using transcranial magnetic stimulation. These deficits—stated as reduced intracortical inhibition in ADHD and shortened cortical silent period in TD—could be seen as neurophysiological correlates of motor hyperactivity and tics, respectively. To investigate neurophysiological aspects of comorbidity, we measured motor system excitability for the first time also in children with combined ADHD and TD. The findings of a reduced intracortical inhibition as well as a shortened cortical silent period in these comorbid children provide evidence for additive effects at the level of motor system excitability. Ann Neurol 2001;49:393–396