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Cell transplantation for stroke
Author(s) -
Savitz Sean I.,
Rosenbaum Daniel M.,
Dinsmore Jonathan H.,
Wechsler Lawrence R.,
Caplan Louis R.
Publication year - 2002
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.60000
Subject(s) - stroke (engine) , transplantation , stromal cell , lesion , medicine , clinical trial , cell , cell type , neuroscience , bioinformatics , pathology , biology , surgery , mechanical engineering , engineering , genetics
Cell transplantation has emerged as an experimental approach to restore brain function after stroke. Various cell types including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are under investigation in experimental and clinical stroke trials. This review discusses the unique advantages and limitations of the different graft sources and emphasizes the current, limited knowledge about their biology. The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion. Ann Neurol 2002;52:266–275