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Reduction in HTLV‐I proviral load and spontaneous lymphoproliferation in HTLV‐I–associated myelopathy/tropical spastic paraparesis patients treated with humanized anti‐tac
Author(s) -
Lehky Tanya J.,
Levin Michael C.,
Kubota Ryuji,
Bamford Richard N.,
Flerlage Alfred N.,
Soldan Samantha S.,
Leist Thomas P.,
Xavier Andrew,
White Jeffrey D.,
Brown Margaret,
Fleisher Thomas A.,
Top Lois E.,
Light Susan,
McFarland Henry F.,
Waldmann Thomas A.,
Jacobson Steven
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410440613
Subject(s) - tropical spastic paraparesis , myelopathy , medicine , human t lymphotropic virus , immunology , antibody , viral load , virology , virus , immune system , spinal cord , psychiatry
Human T‐lymphotropic virus type I (HTLV‐I)‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease that results from an interaction of retroviral infection and immune activation. In this study, five doses (1 mg/kg) of humanized anti‐Tac antibody were administered to 9 HAM/TSP patients at weeks 0,2,6,10, and 14. Preliminary immunological studies on HAM/TSP patients treated with humanized anti‐Tac indicate that there is a selective down‐regulation of activated T cells and a decrease in the HTLV‐I viral load in peripheral blood lymphocytes, most likely through the selective removal of HTLV‐I–infected, activated CD4 + lymphocytes.