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β‐Chemokines MCP‐1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus–associated dementia
Author(s) -
Kelder Wendy,
McArthur Justin C.,
NanceSproson Tish,
McCler Daniel,
Griffin Diane E.
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410440521
Subject(s) - chemokine , dementia , cerebrospinal fluid , immunology , monocyte , macrophage inflammatory protein , ccl2 , medicine , microglia , virus , infiltration (hvac) , human immunodeficiency virus (hiv) , inflammation , virology , disease , pathology , physics , thermodynamics
Human immunodeficiency virus–associated dementia (HAD) is associated with increased numbers of activated central nervous system (CNS) macrophages. Chemokines, which regulate infiltration of macrophages, were measured in the cerebrospinal fluid (CSF) of human immunodeficiency virus (HIV)‐negative and HIV‐positive individuals with and without neurological disese. Monocyte chemotactic protein (MCP)‐1 and RANTES (but not MCP‐3), macrophage inflammatory protein (MIP)‐1α, MIP‐1β, or interleukin‐8 (IL‐8) was higher in HAD. MCP‐1 correlated with CSF viral load and severity of dementia, and it increased over time in patients who developed dementia.