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Genetic contribution of the tumor necrosis factor region in guillain‐barré syndrome
Author(s) -
Ma J. J.,
Nishimura M.,
Mine H.,
Kuroki S.,
Nukina M.,
Ohta M.,
Saji H.,
Obayashi H.,
Kawakami H.,
Saida T.,
Uchiyama T.
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410440517
Subject(s) - guillain barre syndrome , medicine , tumor necrosis factor alpha , tumor necrosis factor α , immunology
We studied genetic polymorphisms in the tumor necrosis factor (TNF) region in 81 Japanese patients with Guillain‐Barré syndrome (GBS) and 85 controls. A significantly higher frequency of the 100–base pair (bp) (TNFa2) allele of the TNFa microsatellite marker, which is associated with high TNFα production, existed in Campylobacter jejuni‐positive (C j + ) GBS patients than in controls, suggesting the involvement of a genetic predisposition to high TNFα secretion in the development of c. jejuni ‐related GBS.