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Presence of 4‐hydroxynonenal in cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis
Author(s) -
Smith R. Glenn,
Henry Y. Kay,
Mattson Mark P.,
Appel Stanley H.
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410440419
Subject(s) - amyotrophic lateral sclerosis , 4 hydroxynonenal , lipid peroxidation , cerebrospinal fluid , oxidative stress , motor neuron , multiple sclerosis , medicine , pathology , cyclic adenosine monophosphate , neuroscience , biology , immunology , disease , receptor
A marker of lipid peroxidation 4‐hydroxynonenal (HNE) was elevated in the cerebrospinal fluid (CSF) of a patient with sporadic amyotrophic lateral sclerosis (sALS) compared with that of most patients with other neurological diseases. Such elevations of HNE were sufficient to kill cyclic adenosine monophosphate (cAMP)‐differentiated motor neuron hybrid cells in vitro, and anti‐oxidants prevented this HNE‐dependent cell death. These data suggest that oxidative stress and lipid peroxidation are associated with and may promote motor neuron degeneration in sALS.