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In vivo differentiation of astrocytic brain tumors and isolated demyelinating lesions of the type seen in multiple sclerosis using 1 H magnetic resonance spectroscopic imaging
Author(s) -
De Stefano Nicola,
Caramanos Zografos,
Preul Mark C.,
Francis Gordon,
Antel Jack P.,
Arnold Douglas L.
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410440222
Subject(s) - multiple sclerosis , magnetic resonance imaging , pathology , medicine , astrocytoma , proton magnetic resonance , demyelinating disease , in vivo , nuclear magnetic resonance , glioma , radiology , biology , physics , immunology , cancer research , microbiology and biotechnology
We used computer pattern recognition of proton magnetic resonance spectroscopic image data to differentiate between brain tumors and large, isolated, demyelinating lesions of the type seen in multiple sclerosis. Leave‐one‐out linear discriminant analyses correctly classified resonance profiles from five acute demyelinating lesions, 20 low‐grade astrocytomas, 22 anoplastic astrocytomas, and 24 glioblastomas. Classification of nonacute lesions will require further development, as the metabolic profiles of demyelinating lesions evolve over time.