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The apolipoprotein E ε4 allele is not a significant risk factor for frontotemporal dementia
Author(s) -
Geschwind Dan,
Karrim Juliana,
Nelson Stanley F.,
Miller Bruce
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410440122
Subject(s) - frontotemporal dementia , apolipoprotein e , allele , age of onset , dementia , medicine , psychology , risk factor , allele frequency , endocrinology , genetics , biology , disease , gene
Frontotemporal dementia (FTD) is the most common early‐onset non‐Alzheimer's dementia (non‐AD). Although the role of the ε4 allele of apolipoprotein E (ApoE) has been well established in AD, studies of ApoE allele distribution in patients with FTD have produced variable results. We studied 33 rigorously diagnosed FTD patients, including several who wre pathologically confirmed, and compared the fequency of the ε4 allele in patients with FTD with the frequency in those with early‐onset AD (EOAD), in those with late‐onset AD (LOAD), and in non‐demented elderly controls. The frequency of ApoE ε4 was 21% in patients with FTD, significantly less than the ApoE ε4 frequency in those patients with EOAD (38%) and those with LOAD (40%), but not significantly different from the ApoE ε4 frequency in elderly controls (13%).