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Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination
Author(s) -
Storch Maria K.,
Piddlesden Sara,
Haltia Matti,
Iivanainen Matti,
Morgan Paul,
Lassmann Hans
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410430409
Subject(s) - remyelination , multiple sclerosis , myelin , lytic cycle , antibody , antigen , immunology , demyelinating disease , medicine , biology , central nervous system , neuroscience , virus
We describe a case of multiple sclerosis characterized by deposition of immunoglobulin and complement in the areas of active demyelination. This was particularly evident for the C9neo antigen, which is a marker for the activated lytic complement complex and was exclusively deposited in the areas of active myelin destruction. In addition, macrophages in the lesions contained degradation products that were immunoreactive for myelin antigens, immunoglobulins, and C9neo antigen. Destruction of myelin sheaths was associated with incomplete loss of oligodendrocytes in the active areas and reappearance of oligodendrocytes with remyelination in the inactive plaque center.