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Stiff‐leg syndrome: A focal form of stiff‐man syndrome
Author(s) -
Saiz Albert,
Graus Francesc,
Valldeoriola Francesc,
VallsSolé Josep,
Tolosa Eduardo
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410430322
Subject(s) - stiff person syndrome , autoantibody , glutamate decarboxylase , autoimmunity , titer , medicine , muscle stiffness , reflex , immunology , antibody , stiffness , biology , biochemistry , structural engineering , engineering , enzyme
We report on 2 patients who presented stiffness and spasms similar to those of stiff‐man syndrome (SMS) that were limited to one leg for up to 11 years. Patients had serum glutamic acid decarboxylase (GAD) autoantibodies in high titer, clinical evidence of organ‐specific autoimmunity, and electromyographic pattern of continuous motor unit activity with abnormally enhanced exteroceptive reflexes. The clinical and immunological profile suggests that this disorder may be a focal form of SMS.