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Cytomegalovirus infection and schizencephaly: Case reports
Author(s) -
Iannetti Paola,
Nigro Giovanni,
Spalice Alberto,
Faiella Antonio,
Boncinelli Edoardo
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410430122
Subject(s) - schizencephaly , polymicrogyria , cytomegalovirus , magnetic resonance imaging , pathogenesis , pathology , medicine , human cytomegalovirus , immunology , radiology , herpesviridae , viral disease , virus
Two children with left open‐lip schizencephaly are reported. Cytomegalovirus (CMV) infection was demonstrated on the second day of life in Patient 1; in the other patient CMV infection was observed at the age of 4 years. Magnetic resonance imaging revealed polymicrogyric cortex lining the clefts. In Patient 2 polymicrogyria was also present in the corresponding area contralateral to the schizencephaly. Computed tomography revealed the presence of subependymal periventricular calcifications. Genetic analysis did not demonstrate the presence of EMX2 homeobox gene. The possible role of CMV infection in the complex multifactorial pathogenesis of schizencephaly is therefore suggested.