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Increased serum levels of soluble CD95 (APO‐1/Fas) in relapsing‐remitting multiple sclerosis
Author(s) -
Zipp Frauke,
Weller Michael,
Calabresi Peter A.,
Frank Joseph A.,
Bash Craig N.,
Dichgans Johannes,
McFarland Henry F.,
Martin Roland
Publication year - 1998
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410430120
Subject(s) - multiple sclerosis , relapsing remitting , fas receptor , medicine , immunology , chemistry , biochemistry , apoptosis , programmed cell death
CD95/CD95 ligand interactions are critically involved in the negative regulation of peripheral T‐cell responses. Here, we report that serum levels of soluble CD95 are significantly elevated in patients with relapsing remitting multiple sclerosis. In a transectional study, CD95 levels did not correlate with clinical disability or lesion formation on magnetic resonance imaging. Longitudinally, Expanded Disability Status Scale changes were associated with high CD95 levels. Interferon‐β (IFNβ) treatment led to an initial increase and subsequent decline of serum CD95 levels. Interestingly, patients generating neutralizing antibodies to the drug had significantly higher baseline CD95 levels before IFNβ treatment than those without neutralizing antibodies.