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Long‐term stroke risk in children with sickle cell disease screened with transcranial doppler
Author(s) -
Adams R. J.,
McKie V. C.,
Carl E. M.,
Nichols F. T.,
Perry R.,
Brock K.,
McKie K.,
Figueroa R.,
Litaker M.,
Weiner S.,
Brambilla D.
Publication year - 1997
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410420505
Subject(s) - transcranial doppler , medicine , stroke (engine) , middle cerebral artery , cardiology , stroke risk , disease , complication , vascular disease , ischemic stroke , ischemia , mechanical engineering , engineering
Stroke is an important complication of sickle cell disease. Stroke prediction is clinically important because it offers the possibility of primary prevention. In 1992, transcranial Doppler (TCD) evidence of elevated intracranial internal carotid or middle cerebral artery velocity was demonstrated to be associated strongly with an increased risk of ischemic stroke. This study extends the original study and includes 125 more children, longer follow‐up, and intracranial hemorrhage in the stroke‐risk model. Elevated time averaged mean maximum blood flow velocity, especially when velocity is 200 cm/sec or greater by TCD, was associated strongly with stroke risk. The cases not predicted by TCD point to the need for more information on the optimal timing of TCD surveillance for stroke risk.