Coenzyme Q 10  levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects | Zendy

Shults Clifford W. | Zendy; Haas Richard H. | Zendy; Passov David | Zendy; Beal M. Flint | Zendy

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Coenzyme Q 10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

Author(s) -

Shults Clifford W.,

Haas Richard H.,

Passov David,

Beal M. Flint

Publication year - 1997

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410420221

Subject(s) - coenzyme q – cytochrome c reductase , mitochondrion , cofactor , parkinson's disease , medicine , endocrinology , chemistry , disease , biochemistry , biology , enzyme , cytochrome c

The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q 10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q 10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age‐ and sex‐matched control subjects and that the levels of coenzyme Q 10 and the activities of complex I and complex II/III were significantly correlated.

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