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α 1 ‐Antichymotrypsin as a risk modifier for late‐onset Alzheimer's disease in Japanese apolipoprotein E ε4 allele carriers
Author(s) -
Yoshiiwa A.,
Kamino K.,
Yamamoto H.,
Kobayashi T.,
Imagawa M.,
omura Y.,
Yoneda H.,
Sakai T.,
Nishiwaki Y.,
Sato N.,
Rakugi H.,
Miki T.,
Ogihara T.
Publication year - 1997
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410420118
Subject(s) - allele , apolipoprotein e , odds ratio , alzheimer's disease , allele frequency , genetics , age of onset , population , disease , medicine , biology , gene , environmental health
In the Japanese population, sporadic late‐onset Alzheimer's disease (LOAD) cases had significantly higher frequencies of the A allele of α 1 −antichymotrypsin (ACT) gene as well as the $4 allele of apolipoprotein E (APOE) gene than controls. The odds ratio for LOAD in APOE4 carriers with the ACT‐A allele was more than six times that in APOE4 carriers without the ACT‐A allele (21.1 vs 3.2). These results indicate that the ACT‐A allele is a risk modifier for LOAD in APOE4 carriers.