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Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13?
Author(s) -
Wilhelmsen K.,
Mirel D.,
Marder K.,
Bernstein M.,
Naini A.,
Leal S. M.,
Cote L. J.,
Tang M.X.,
Freyer G.,
Graziano J.,
Mayeux R.
Publication year - 1997
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410410619
Subject(s) - genetics , linkage disequilibrium , locus (genetics) , cyp2d6 , parkinson's disease , biology , allele , genetic association , genotype , haplotype , disease , gene , single nucleotide polymorphism , medicine
The cytochrome P450 mono‐oxygenase gene, CYP2D6 on chromosome 22q13 (ch22q13), has been inconsistently associated with Parkinson's disease. Associations with CYP2D6 have either been absent altogether or have involved more than one polymorphism, many of which have the same metabolic effect on gene expression. We examined the association between CYP2D6 polymorphisms and Parkinson's disease in a case‐control study and included 10 polymorphic dinucleotide repeat markers linked to CYP2D6 to determine whether the association was present or due to linkage disequilibrium. There was no association between any polymorphism of CYP2D6 and Parkinson's disease, but two of 10 dinucleotide repeat markers linked to CYP2D6 were associated with the disease. These results provide evidence to suggest that there may be an unidentified locus for susceptibility to Parkinson's disease that is in linkage disequilibrium with dinucleotide repeat markers mapping near CYP2D6 on ch22q13.