A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele | Zendy

Ikeda Kenji | Zendy; Akiyama Haruhiko | Zendy; Arai Tetsuaki | Zendy; Sahara Naruhiko | Zendy; Mori Hiroshi | Zendy; Usami Mihoko | Zendy; Sakata Masuhiro | Zendy; Mizutani Toshio | Zendy; Wakabayashi Koichi | Zendy; Takahashi Hitoshi | Zendy

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A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele

Author(s) -

Ikeda Kenji,

Akiyama Haruhiko,

Arai Tetsuaki,

Sahara Naruhiko,

Mori Hiroshi,

Usami Mihoko,

Sakata Masuhiro,

Mizutani Toshio,

Wakabayashi Koichi,

Takahashi Hitoshi

Publication year - 1997

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410410522

Subject(s) - apolipoprotein e , allele , incidence (geometry) , senile dementia , dementia , medicine , genetics , biology , mathematics , disease , gene , geometry

There is a subset of very elderly patients with senile dementia in whom abundant neurofibrillary tangles are present, mainly in the hippocampal region, without a significant number of senile plaques. In a retrospective neuropathological examination of 239 dementia patients, 14 were found to have this type of senile dementia. The apolipoprotein E ϵ2, ϵ3, and ϵ4 allele frequencies in this patient group were 0.39, 0.50, and 0.11, respectively. Such a high frequency of the ϵ2 allele suggests that this type of dementia is distinct from Alzheimer's disease not only from a neuropathological but also from a genetic viewpoint.

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