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A subset of senile dementia with high incidence of the apolipoprotein E ϵ2 allele
Author(s) -
Ikeda Kenji,
Akiyama Haruhiko,
Arai Tetsuaki,
Sahara Naruhiko,
Mori Hiroshi,
Usami Mihoko,
Sakata Masuhiro,
Mizutani Toshio,
Wakabayashi Koichi,
Takahashi Hitoshi
Publication year - 1997
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410410522
Subject(s) - apolipoprotein e , allele , incidence (geometry) , senile dementia , dementia , medicine , genetics , biology , mathematics , disease , gene , geometry
There is a subset of very elderly patients with senile dementia in whom abundant neurofibrillary tangles are present, mainly in the hippocampal region, without a significant number of senile plaques. In a retrospective neuropathological examination of 239 dementia patients, 14 were found to have this type of senile dementia. The apolipoprotein E ϵ2, ϵ3, and ϵ4 allele frequencies in this patient group were 0.39, 0.50, and 0.11, respectively. Such a high frequency of the ϵ2 allele suggests that this type of dementia is distinct from Alzheimer's disease not only from a neuropathological but also from a genetic viewpoint.