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Soluble adhesion molecules (sVCAM‐1 and sICAM‐1) in cerebrospinal fluid and serum correlate with MRI activity in multiple sclerosis
Author(s) -
Rieckmann Peter,
Altenhofen Bernd,
Riegel Antje,
Baudewig Jürgen,
Felgenhauer Klaus
Publication year - 1997
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410410307
Subject(s) - multiple sclerosis , cerebrospinal fluid , cell adhesion molecule , medicine , adhesion , pathology , immunology , chemistry , organic chemistry
We performed a prospective study to correlate quantitative brain magnetic resonance imaging activity (gadolinium‐diethylenetriaminepentaacetic acid enhancement) to cerebrospinal fluid and serum levels of soluble adhesion molecules in 46 patients with newly diagnosed multiple sclerosis (MS) and 30 control subjects with other diseases of the central nervous system. In all patients, magnetic resonance imaging of the brain and lumbar puncture were performed on the same day. In 32 (70%) of 46 MS patients, 8 (80%) of 10 patients with acute viral encephalitis, but none of the control subjects with noninflammatory diseases, gadolinium‐enhancing lesions were detected. There was a significant correlation between the cerebrospinal fluid/serum ratios for soluble intercellular adhesion molecule‐1 and soluble vascular cell adhesion molecule‐1 as well as serum levels for both molecules and the area of gadolinium‐enhancing lesions. No obvious correlation was observed between magnetic resonance imaging findings and cerebrospinal fluid cell count, protein concentration, or intrathecal immunoglobulin production. In patients with a single periventricular gadolinium‐enhancing lesion (n = 16), we observed a strong negative correlation between the distance from the lateral ventricles and the cerebrospinal fluid/serum ratios for soluble intercellular adhesion molecule‐1/albumin and soluble vascular cell adhesion molecule‐1/albumin. These results suggest that intrathecal production of the two soluble adhesion molecules, as well as serum levels for soluble vascular cell adhesion molecule‐1, in patients with MS reflect magnetic resonance imaging activity of typical periventricular lesions.