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Mitochondrial function in muscle from elderly athletes
Author(s) -
Brierley Elizabeth J.,
Johnson Margaret A.,
Bowman Andrew,
Ford Gary A.,
Subhan Feisel,
Reed James W.,
James OliverF. W.,
Turnbull Douglass M.
Publication year - 1997
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410410120
Subject(s) - mitochondrion , athletes , mitochondrial respiratory chain , skeletal muscle , respiratory chain , respiratory system , medicine , disease , sarcopenia , physiology , biology , gerontology , physical therapy , microbiology and biotechnology
The extent to which mitochondria are involved in the aging process is conttroversial; much of the reported decline in mitochondrial oxidations in human skeletal muscle may be due to disease and inactivity rather than age. To study true aging, mitochondrial respiratory chain function was studied in 9 young and 12 elderly athletes. No significant deterioration with age was observed. If mitochondria are involved in aging, it must be through a more subtle mechanism than a global decline in respiratory chain activity.