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Stereotactic thalamotomy in tremor‐dominant Parkinson's disease: An H 2 15 O PET motor activation study
Author(s) -
Boecker Henning,
Wills Adrian J.,
CeballosBaumann Andres,
Samuel Michael,
Thomas David G. T.,
Marsden C. David,
Brooks David J.
Publication year - 1997
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410410118
Subject(s) - thalamotomy , premotor cortex , thalamus , supplementary motor area , essential tremor , parkinson's disease , medicine , neuroscience , motor cortex , cortex (anatomy) , movement disorders , physical medicine and rehabilitation , psychology , disease , anatomy , functional magnetic resonance imaging , deep brain stimulation , dorsum , pathology , stimulation
Stereotactic thalamotomy is an effective treatment for severe drug‐resistant tremor. The thalamus, however, facilitates motor activiry, and thalamotomy would be predicted to inhibit movement‐associated cortical activation. Two tremulous parkinsonian patients were studied with H 2 15 O position emission tomography before and after left ventalis intermedius thalamotomy. Subjects were scanned at rest and during performance of externally paced joystick movements in freely selected direstions with the right hand. Thalamotomy relieved tremor but, as perdicted, led to dercreased activation of the left sensorimotor cortex, lateral premotor cortex, and parietal area 7 on hand movement.