Premium
Onset of dementia is associated with apolipoprotein E ε4 in Down's syndrome
Author(s) -
Schupf Nicole,
Lee Joseph H.,
Kapell Deborah,
Zigman Warren,
Canto Basilisa,
Tycko Benjamin,
Mayeux Richard
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410400518
Subject(s) - dementia , medicine , apolipoprotein e , psychology , neuroscience , disease
We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented ( RR = 4.7; 95% CI = 1.2, 17.9). We hypothesize that the increased risk of dementia may be mediated by exacerbation of β‐amyloid deposition.