Premium
Cognitive and brain magnetic resonance imaging findings in adrenomyeloneuropathy
Author(s) -
Edwin David,
Speedie Lynn J.,
Kohler Wolfgang,
Naidu Sakkubai,
Moser Hugo W.,
Kruse Bernd
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410400419
Subject(s) - neuropsychology , magnetic resonance imaging , psychomotor learning , cognition , psychology , white matter , medicine , audiology , adrenoleukodystrophy , visual memory , neuroscience , radiology , peroxisome , receptor
Neuropsychological functioning and brain magnetic resonance imaging (MRI) were evaluated in 84 men with adrenomyeloneuropathy (AMN). MRI was normal in 61%, the “pure AMN” group, while 39%, the “cerebral AMN” group, showed brain white matter abnormalities. Except for mild deficits in psychomotor speed and visual memory, neuropsychological function was normal in pure AMN. Most patients with cerebral AMN had normal IQ and language but evidenced impaired psychomotor speed, spatial cognition, memory, and executive functions. Patients with MRI evidence of very severe cerebral disease had global and language impairment as well, and deficits in all patients were highly correlated with degree of brain MRI involvement.