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The glial glutamate transporter complementary DNA in patients with amyotrophic lateral sclerosis
Author(s) -
Meyer Thomas,
Meyer Bientje,
Sitte Wolfgang,
Ludolph Albert C.,
Speer Astrid,
Küther Gerald
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410400317
Subject(s) - amyotrophic lateral sclerosis , excitatory amino acid transporter , glutamate receptor , mutation , transporter , coding region , medicine , dna , biology , genetics , gene , neuroscience , disease , pathology , receptor
Here, we report a mutation screening by single‐stranded conformational analysis of the astroglial human brain glutamate transporter (HBGT) II complementary DNA in patients with amyotrophic lateral sclerosis. The conformational analysis data indicate a lack of sequence variations in the HBGT II coding region in 6 patients with amyotrophic lateral sclerosis and the same number of nonneurological control subjects. In both groups, three variants of the HBGT II 5′ untranslated region were isolated. We have no evidence that the reported complementary DNA variants are disease specific.