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Genetic studies in Alzheimer's disease with an NACP/α‐synuclein polymorphism
Author(s) -
Xia Yu,
de Silva H. A. Rohan,
Rosi Barbara L.,
Yamaoka Larry H.,
Rimmler Jacqueline B.,
PericakVance Margaret A.,
Roses Allen D.,
Chen Xiaohua,
Masliah Eliezer,
Deteresa Richard,
Iwai Akihiko,
Sundsmo Mary,
Thomas Ronald G.,
Hofstetter C. Richard,
Gregory Ethan,
Hansen Lawrence A.,
Katzman Robert,
Thal Leon J.,
Saitoh Tsunao
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410400212
Subject(s) - alzheimer's disease , allele , disease , amyloid (mycology) , genetics , genetic linkage , apolipoprotein e , medicine , biology , gene , pathology
The non‐Aß component of Alzheimer's disease amyloid (NAC) is copurified with amyloid from the brain tissue of Alzheimer's disease victims and is immunohistochemically localized to amyloid fibrils. NAC is a hydrophobic peptide fragment from the NAC precursor protein (NACP/α‐synuclein) that is localized to presynaptic terminals. We used a polymorphic dinucleotide repeat sequence in a genomic clone of NACP for genetic association and linkage studies. Screening of Alzheimer's disease families failed to establish linkage between NACP and Alzheimer's disease. Nevertheless, one of the NACP polymorphisms (NACP allele 2) was shown to have significant association with healthy elderly control individuals with apolipoprotein E risk. This may indicate a possible protective function of the allele.