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DR2/DQwl Inheritance and haplotype sharing in affected siblings from multiple sclergis families
Author(s) -
Voskuhl Rhonda R.,
Goldstein Alisa M.,
Voskuhl Toni,
Davey Richard J.,
McFarland Henry F.
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410390618
Subject(s) - haplotype , inheritance (genetic algorithm) , sibling , genetics , genealogy , biology , evolutionary biology , psychology , developmental psychology , allele , gene , history
Although the human leukocyte antigen DFWDQwl allele has been associated with multiple sclerosis, studies of DRZ/DQwl inheritance in multiple sclerosis multiplex families have yielded conflicting results. We examined this question in “highincidence” families, defined as families with more than 50% of siblings affected. DR2/ DQwl allele frequencies were significantly increased, particularly in mothers and affected siblings ( p < 0.0001). The transmission of DR2IDQwl from both parents was more frequent in affected offspring ( p = 0.005). While evidence for segregation of disease with a particular parental allele was lacking in most families, the frequency of haplotype sharing was higher in affected sib pairs ( p < 0.01).