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Use of anti‐neurofilament antibody to identify paired‐helical filaments in inclusion‐body myositis
Author(s) -
Askanas Valerie,
Alvarez Renate B.,
Mirabella Massimiliano,
Engel W. King
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410390318
Subject(s) - inclusion body myositis , neurofilament , antibody , myositis , medicine , pathology , immunology , immunohistochemistry
Paired‐helical filaments (PHF s ) are an important diagnostic criterion of the inclusion‐body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHF s by light microscopy. This procedure greatly facilitates diagnosis of IBM.