Use of anti‐neurofilament antibody to identify paired‐helical filaments in inclusion‐body myositis | Zendy

Askanas Valerie | Zendy; Alvarez Renate B. | Zendy; Mirabella Massimiliano | Zendy; Engel W. King | Zendy

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Use of anti‐neurofilament antibody to identify paired‐helical filaments in inclusion‐body myositis

Author(s) -

Askanas Valerie,

Alvarez Renate B.,

Mirabella Massimiliano,

Engel W. King

Publication year - 1996

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410390318

Subject(s) - inclusion body myositis , neurofilament , antibody , myositis , medicine , pathology , immunology , immunohistochemistry

Paired‐helical filaments (PHF s ) are an important diagnostic criterion of the inclusion‐body myositis (IBM) muscle biopsy; but, until now, their presence could be identified only by electronmicroscopy. In this report, we describe an easy immunocytochemical procedure, utilizing commercially available antibody, that enables reliable identification of muscle PHF s by light microscopy. This procedure greatly facilitates diagnosis of IBM.

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