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Hypoplasia of the cerebellar vermis in neurogenetic syndromes
Author(s) -
Schaefer G. Bradley,
Thompson James N.,
Bodensteiner John B.,
McConnell James M.,
Kimberling William J.,
Gay Charles T.,
Dutton William D.,
Hutchings David C.,
Gray Stanton B.
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410390316
Subject(s) - cerebellar vermis , cerebellar hypoplasia (non human) , cerebellum , hypoplasia , autism , neuroscience , magnetic resonance imaging , psychology , anatomy , pathology , biology , medicine , developmental psychology , radiology
There are conflicting reports on the relationship between cerebellar vermal lobule hypoplasia and autism. Using quantitative magnetic resonance image analysis, we measured the cerebellar vermis in 125 normal individuals with a broad age range and 102 patients with a variety of neurogenetic abnormalities. We conclude that hypoplasia of cerebellar vermal lobules VI and VII is a nonspecific finding that even occurs in several conditions without autistic behavior. This suggests that it is not a specific neuroanatomical marker for autism, nor is cerebellar dys‐ genesis likely to be solely responsible for clinical autistic behaviors.