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HLA Class II genes associated with REM sleep behavior disorder
Author(s) -
Schenck Carlos H.,
GarciaRill Edgar,
Segall Miriam,
Noreen Harriet,
Mahowald Mark W.
Publication year - 1996
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410390216
Subject(s) - narcolepsy , rem sleep behavior disorder , sleep (system call) , human leukocyte antigen , psychology , rapid eye movement sleep , medicine , psychiatry , polysomnography , immunology , antigen , neurology , apnea , computer science , operating system , electroencephalography
Twenty‐five white men with rapid eye movement (REM) sleep behavior disorder, but without narcolepsy, under‐went HLA class II antigen typing; 84% (N = 21) were DQw1 (DQB1*05,06) positive (28% [N = 7] were DR2 positive); DQB1*0501 (N = 9) and DQB1*0602 (N = 7) were the most common phenotypes. The 84% DQwl rate in men with REM sleep behavior disorder was significantly greater ( p = 0.015) than the 56% DQwl rate found in a local white comparison group (N = 66), and was greater than the 39 to 66% DQw1 rates published for 12 white groups (N = 40–418/group). Thus, another disorder of REM sleep dysregulation (besides narcolepsy) appears to be strongly associated with specific HLA class I1 genes.