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Apolipoprotein E genotypes and age of onset in early‐onset familial Alzheimer's disease
Author(s) -
LevyLahad Ephrat,
Lahad Am,
Wijsman Ellen M.,
Bird Thomas D.,
Schellenberg Gerard D.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410380420
Subject(s) - apolipoprotein e , age of onset , allele , locus (genetics) , genotype , early onset alzheimer's disease , alzheimer's disease , disease , genetics , degenerative disease , biology , medicine , gene
The effect of the apolipoprotein E (APOE) ϵ4 allele on age of onset was analyzed in two groups of families with early‐onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early‐onset non‐VG families showing evidence of linkage to chromosome 14. The ϵ4 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early‐onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE‐independent pathways.