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Neuroborreliosis in the nonhuman primate: Borrelia burgdorferi persists in the central nervous system
Author(s) -
Pachner Andrew R.,
Delaney Elizabeth,
O'Neill Tim
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410380417
Subject(s) - borrelia burgdorferi , lyme neuroborreliosis , lyme disease , neuroborreliosis , spirochaetaceae , biology , central nervous system , polymerase chain reaction , borrelia , virology , immunology , pathology , medicine , neuroscience , genetics , antibody , gene
Abstract Neurological involvement in Lyme disease is common, and is frequently difficult to diagnose and treat. Little is known about the fate of the causative spirochete Borrelia burgdorferi in the central nervous system (CNS). To determine the frequency of parenchymal infection and to determine localization of the organism, polymerase chain reaction/hybridization assays were performed in a newly described model of Lyme neuroborreliosis in nonhuman primates infected with B. burgdorferi . Polymerase chain reaction/hybridization of CNS tissues from 5 infected nonhuman primates was performed. Substantial amounts of B. burgdorferi DNA were detected in the CNS in all infected animals, with a predilection toward subtentorial structures. These data suggest that Lyme neuroboreliosis represents persistent infection with B. burgdorferi .

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