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Cerebral transport and metabolism of 1‐ 11 C‐ D ‐glucose during stepped hypoglycemia
Author(s) -
Powers William J.,
DagogoJack Samuel,
Markham Joanne,
Larson Kenneth B.,
Dence Carmen S.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410380408
Subject(s) - positron emission tomography , glucose transporter , carbohydrate metabolism , hypoglycemia , venous blood , metabolism , endocrinology , medicine , glucose uptake , chemistry , blood sampling , nuclear medicine , diabetes mellitus , insulin
Attempts to measure blood‐to‐brain glucose transport and cerebral glucose metabolism with 11 C‐glucose have been hampered by methods that require jugular venous sampling or do not adequately account for the efflux of labeled metabolites from the brain. We performed eight positron emission tomography studies with 1‐ 11 C‐d‐glucose in macaques at arterial plasma glucose concentrations of 8.43 to 1.51 μmol ml −1 (152–27 mg dl −1 ) using a model that includes a fourth rate constant to account for regional egrees of all 11 C‐metabolites. Values for blood‐to‐brain glucose influx, cerebral glucose metabolism, and brain free glucose concentration agreed closely with values obtained in mammals by other investigators. Values for net extraction fraction corresponded closely to simultaneously measured arteriovenous values. We demonstrated that utilization of a model that includes a fourth rate constant to account for regional egress of all 11 C‐metabolites with positron emission tomography and 1‐ 11 C‐d‐glucose provides accurate measurements of blood‐to‐brain glucose transport and cerebral glucose metabolism in vivo without need for jugular venous sampling, even under conditions of severe hypoglycemia.