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Decreased single‐photon emission computed tomographic { 123 I}β‐CIT striatal uptake correlates with symptom severity in parkinson's disease
Author(s) -
Seibyl J. P.,
Marchek K. L.,
Quinlan D.,
Sheff K.,
Zoghbi S.,
ZeaPonce Y.,
Baldwin R. M.,
Fussell B.,
Smith E. O.,
Charney D. S.,
Hoffer P. B.,
Innis R. B.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410380407
Subject(s) - putamen , caudate nucleus , parkinson's disease , single photon emission computed tomography , striatum , central nervous system disease , nuclear medicine , medicine , gastroenterology , psychology , disease , dopamine
Previous studies have utilized single‐photon emission computed tomography (SPECT) to demonstrate decreased { 123 I}β‐CIT striatal uptake in idiopathic Parkinson disease (PD) patients. The present study extendss this work by examining SPECT outcome measures in a larger group of PD patients with varying disease severity. Twenty‐eight l‐dopa‐responsive PD patients (Hoehn‐Yahr stages 1–4) and 27 healthy controls had SPECT scans at 18 to 24 hours after injection of { 123 I}β‐CIT. Specific to nondisplaceable striatal uptake ratios (designated V 3″ ) were correlated with Hoehn‐Yahr stage and Unified Parkinson's Disease Rating Scale (UPDRS) subscores. Linear discriminant function analyses utilizing striatal uptakes, putamen‐to‐caudate ratios, and ipsilateral‐contralateral asymmetry indices were performed. Decreased striatal tracer uptake ( V 3″ ) was correlated with total UPDRS score for both contralateral and ipsilateral striatum. Putamen uptake was relatively more reduced than caudate with mean putamen:caudate ratios of 0.50 ± 0.17 and 0.82 ± 0.09 for PD patients and controls, respectively. Ipsilateral:contralateral asymmetry was significantly greater in PD patients than controls. Discriminant function analysis utilizing V 3″ for ipsilateral and contralateral caudate and putamen correctly classified all 55 cases. These data demonstrate Marchked differences in { 123 I}β‐CIT SPECT measures in healthy controls and PD patients. The significant correlation of SPECT measures with motor severity suggests { 123 I}β‐CIT may be a useful Marchker of disease severity in PD.