Premium
Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging
Author(s) -
Hartung HansPeter,
Reiners Karlheinz,
Archelos Juan J.,
Michels Marco,
Seeldrayers Pierrette,
Heidenreich Fedor,
Pflughaupt Karl W.,
Toyka Klaus V.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410380210
Subject(s) - tumor necrosis factor alpha , cell adhesion molecule , e selectin , receptor , multiple sclerosis , cytokine , magnetic resonance imaging , selectin , medicine , cell adhesion , vcam 1 , pathology , l selectin , immunology , inflammation , necrosis , endocrinology , chemistry , cell , icam 1 , biochemistry , radiology
Adhesion molecules are important in T‐cell trafficking to sites of inflammation. We determined levels of circulating vascular cell adhesion molecule‐1 (VCAM‐1), L‐selectin, and E‐selectin in the serum of 147 patients with definite multiple sclerosis of the remitting‐relapsing or secondary progressive type. Soluble VCAM‐1 and L‐selectin concentrations were increased compared to levels in a large group of control subjects. Levels were highest in patients with gadolinium‐enhancing lesions on magnetic resonance imaging (VCAM‐1: 1,011 ± 276 vs 626 ± 87 ng/ml; L‐selectin: 1,130 ± 272 vs 793 ± 207 ng/ml [mean ± standard deviation]; p > 0.0001 vs patients without enchancing lesions). Serum levels of soluble tumor necrosis factor receptor (60 kd) were also raised (2.64 ± 1.23 vs 2.17 ± 0.69 ng/ml in subjects with other neurological diseases and 2.1 ± 0.77 ng/ml in healthy control subject; p < 0.05). Soluble VCAM‐1 and L‐selectin levels were correlated to concentrations of soluble tumor necrosis factor receptor. In 13 patients with viral encephalitis, similar observations were made. Raised levels of soluble VCAM‐1 and L‐selectin probably reflect cytokine‐induced endothelial cell and T‐lymphocyte/monocyte activation occurring in the process of T‐cell migration into the central nervous system. Tumor necrosis factor‐alpha may be critically involved.