Premium
Studies of the coding region of the neuronal glutamate transporter gene in amyotrophic lateral sclerosis
Author(s) -
Meyer T.,
Lenk U.,
Küther G.,
Weindl A.,
Speer A.,
Ludolph A. C.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410370618
Subject(s) - amyotrophic lateral sclerosis , excitatory amino acid transporter , glutamate receptor , gene , neuroscience , transporter , degenerative disease , genetics , medicine , biology , disease , central nervous system disease , pathology , receptor
Abstract Studies of the coding region of the neuronal glutamate transporter of 6 amyotrophic lateral sclerosis (ALS) patients and 10 controls show an identical pattern of four reported amino acid variations. No mutations and polymorphisms were detected in 5 sporadic ALS patients and a single patient with the familial form of the disease.