Premium
Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy
Author(s) -
Garcia Paul A.,
Laxer Kenneth D.,
van der Grond Jeroen,
Hugg James W.,
Matson Gerald B.,
Weiner Michael W.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410370222
Subject(s) - epilepsy , frontal lobe , temporal lobe , magnetic resonance imaging , proton magnetic resonance , hippocampus , medicine , creatine , magnetic resonance spectroscopic imaging , nuclear magnetic resonance , nuclear medicine , neuroscience , psychology , radiology , physics
Proton magnetic resonance spectroscopic imaging ( 1 H MRSI) has demonstrated decreased N ‐acetyl compounds (NA) in the epileptogenic hippocampus in patients with temporal lobe epilepsy. We studied 8 patients with frontal lobe epilepsy and found mean NA/creatine (Cr) in the epileptogenic frontal lobe decreased by 27% compared with that of the contralateral homologous region (1.81 ±0.36 vs 2.49 ± 0.60, p < 0.008). In every patient, NA/Cr was decreased in the epileptogenic region by at least 5%. These findings suggest that 1 H MRSI may be useful in the presurgical evaluation of patients with frontal lobe epilepsy.