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Concentrations of amyloid β protein in cerebrospinal fluid of patients with alzheimer's disease
Author(s) -
Van Gool W. A.,
Walstra G. J. M.,
Bolhuis P. A.,
Kuiper M. A.,
Wolters E. Ch
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410370221
Subject(s) - cerebrospinal fluid , disease , pathology , amyloid (mycology) , alzheimer's disease , medicine , amyloid β , degenerative disease
Deposition of fibrillar amyloid β protein (Aβ) is increased in brains of patients with Alzheimer's disease. Concentrations of Aβ were measured in cerebrospinal fluid with an enzyme‐linked immunosorbent assay in 10 neurological patients free from neurodegenerative disease, 28 patients with Parkinson's disease, and 18 patients with probable Alzheimer's disease. Levels of Aβ in cerebrospinal fluid were not significantly different among these groups. This observation suggests that concentrations of soluble Aβ in cerebrospinal fluid as measured in this study do not reflect the amount of fibrillar, aggregated Aβ in the brain of patients with Alzheimer's disease.