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Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans
Author(s) -
Hendrie H. C.,
Hall K. S.,
Hui S.,
Unverzagt F. W.,
Yu C. E.,
Lahiri D. K.,
Sahota A.,
Farlow M.,
Musick B.,
Brashear A.,
Burdine V. E.,
Osuntokun B. O.,
Ogunniyi A. O.,
Gureje O.,
Baiyewu O.,
Schellenberg G. D.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410370123
Subject(s) - allele , apolipoprotein e , genotype , alzheimer's disease , disease , allele frequency , degenerative disease , medicine , population , case control study , polymorphism (computer science) , genetics , gerontology , biology , gene , environmental health
As part of a community‐based study of Alzheimer's disease (AD) in the African‐American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The €4 allele of Apo E was strongly associated with AD in this population sample. The € allele frequency in AD patients was 40.3% compared with 13.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects ( p = 0.01). This study extends the association of Apo E‐∈4 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.