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The CYP2D6B mutant allele is overrepresented in the Lewy body variant of Alzheimer's disease
Author(s) -
Saitoh T.,
Xia Y.,
Chen X.,
Masliah E.,
Galasko D.,
Shults C.,
Thal L. J.,
Hansen L. A.,
Katzman R.
Publication year - 1995
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410370120
Subject(s) - lewy body , allele , alzheimer's disease , disease , degenerative disease , mutant , genetics , lewy body disease , biology , medicine , dementia , dementia with lewy bodies , gene
Abstract Approximately one‐fourth of neuropathologically confirmed cases of Alzheimer's disease (AD) also have brainstem and neocortical Lewy bodies, constituting a Lewy body variant of AD. Because Lewy bodies are a pathologic hallmark of Parkinson's disease (PD), this subpopulation of AD subjects may have the same risk factors as PD subjects. Analyses of the cytochrome P450 CYP2D6‐debrisoquine 4‐hydroxylase mutant B allele, a susceptibility gene for PD, revealed a higher representation of this allele in the Lewy body variant of AD than in pure AD or non‐AD without Lewy bodies.