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Magnetic resonance imaging in the evaluation of clinical trials in multiple sclerosis
Author(s) -
Paty Donald W.,
Li David K. B.,
Oger Joël J.F.,
Kastrukoff Lorne,
Koopmans Robert,
Tanton Elizabeth,
Zhao Gou Jun
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410360721
Subject(s) - multiple sclerosis , magnetic resonance imaging , clinical trial , medicine , drug trial , radiology , pathology , psychiatry
Magnetic resonance imaging (MRI) provides an objective method of evaluating multiple sclerosis clinical trials and is at least five times more sensitive to disease activity. In a recent clinical trial, MRI was also approximately twice as sensitive as clinical measurements to the treatment effect of a drug.