Premium
Genetics and multiple sclerosis: An overview
Author(s) -
Ebers George C.
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410360705
Subject(s) - concordance , epistasis , trait , genetics , multiple sclerosis , biology , locus (genetics) , major histocompatibility complex , multifactorial inheritance , genetic linkage , linkage (software) , evolutionary biology , computer science , gene , single nucleotide polymorphism , genotype , immunology , programming language
Abstract There is evidence to support the view that multiple sclerosis is a complex trait determined by both genetic and environmental factors. The genetic component is reflected in the higher rate of concordance in monozygotic versus dizygotic twins and in familial recurrence risk data. These data fit best with oligogenic hypotheses encompassing epistatic interaction. However, confirmation will require comprehensive linkage studies using techniques that can rapidly screen the entire genome. The number of families required to demonstrate the effects of a locus such as the major histocompatibility complex is very large.