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Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy
Author(s) -
Henry Thomas R.,
Babb Thomas L.,
Engel Jerome,
Mazziotta John C.,
Phelps Michael E.,
Crandall Paul H.
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410360620
Subject(s) - ictal , temporal lobe , epilepsy , diaschisis , hippocampal formation , neuroscience , positron emission tomography , hippocampal sclerosis , pathophysiology , mesial temporal lobe epilepsy , medicine , psychology , pathology , cerebellum
Abstract The pathophysiology of widespread interictal hypometabolism in temporal lobe epilepsy is unknown but might reflect neuronal loss and diaschisis. We found no significant correlation between any cortical region's metabolism on preoperative { 18 F} fluorodeoxyglucose positron emission tomography and neuronal density of resected hippocampi in 40 patients. We conclude that hippocampal neuronal loss and diaschisis cannot account for the regional interictal hypometabolism of temporal lobe epilepsy.