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Increased risk of Parkinson's disease in parents and siblings of patients
Author(s) -
Payami Haydeh,
Larsen Kimberly,
Bernard Steven,
Nutt John
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410360417
Subject(s) - first degree relatives , odds ratio , etiology , incidence (geometry) , medicine , disease , family history , confidence interval , cumulative incidence , parkinson's disease , epidemiology , pediatrics , cohort , physics , optics
Abstract We studied the incidence of Parkinson's disease in 586 first‐degree relatives (parents and siblings) of 114 randomly ascertained white patients with idiopathic Parkinson's disease and in 522 first‐degree relatives of 114 age‐matched unrelated white control subjects. Sixteen percent of patients had a family history as compared to 4% of control subjects ( p < 0.01). The age‐specific cumulative incidence was higher in the first‐degree relatives of patients than in the first‐degree relatives of control subjects ( p = 0.007). The age‐adjusted odds ratio was 3.5 (95% confidence interval: 1.3–9.4; p = 0.014). These results suggest that genes contribute to the etiology of Parkinson's disease.