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Dose‐dependent association of apolipoprotein e allele ε4 with late‐onset, sporadic Alzheimer's disease
Author(s) -
Yoshizawa Toshihiro,
YamakawaKobayashi Kimiko,
Komatsuzaki Yasuko,
Arinami Tadao,
Oguni Ei'ichi,
Mizusawa Hidehiro,
Shoji Shin'ichi,
Hamaguchi Hideo
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410360416
Subject(s) - odds ratio , apolipoprotein e , age of onset , medicine , alzheimer's disease , disease , risk factor , confidence interval , allele , gastroenterology , degenerative disease , biology , genetics , gene
We examined the apolipoprotein E (apo E) genotypes in 47 patients with late‐onset sporadic Alzheimer's disease (mean age at onset ± standard deviation, 72.2 ± 6.4 years), 8 with late‐onset familial Alzheimer's disease (75.5 ± 5.1 years), 18 with early‐onset sporadic Alzheimer's disease (52.8 ± 4.7 years), and 10 with early‐onset familial Alzhemer's disease (52.0 ± 6.8 years) in Japan and compared them with genotypes in control subjects. In late‐onset sporadic Alzheimer's disease, apo E‐ε4 frequency increased significantly (ε4 frequency: 0.34 vs 0.095 in controls, p < 0.0001), and the odds ratio, which represents the strength of association between Alzheimer's disease and apo E‐ε4 gene (3 [95% confidence interval, 2–6] in one dose; 43 [95% confidence interval, 12–154] in two doses). This study also suggested that apo E‐ε4 is associated with both late‐onset (ε4: 0.31) and early‐onset familial Alzheimer's disease (ε4: 0.35). In contrast, we found no association between apo E‐ε4 and early‐onset sporadic Alzheimer's disease (ε4: 0.08). These results indicate that the risk of developing late‐onset sporadic Alzheimer's disease is markedly dependent on the dose of apo E‐ε4, while apo E‐ε4 does not appear to be a major risk factor for early‐onset sporadic Alzheimer's disease.