Decreased cerebrospinal fluid levels of β‐endorphin in Japanese patients with Joseph disease | Zendy

Matsuishi Toyojiro | Zendy; Sakai Tetsuo | Zendy; Nagamitsu Shinichiro | Zendy; Komori Hironori | Zendy; Iwashita Hiroshi | Zendy; Kato Hiroshisa | Zendy

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Decreased cerebrospinal fluid levels of β‐endorphin in Japanese patients with Joseph disease

Author(s) -

Matsuishi Toyojiro,

Sakai Tetsuo,

Nagamitsu Shinichiro,

Komori Hironori,

Iwashita Hiroshi,

Kato Hiroshisa

Publication year - 1994

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410360317

Subject(s) - cerebrospinal fluid , beta endorphin , disease , medicine , gastroenterology , beta (programming language) , computer science , programming language

We measured the cerebrospinal fluid (CSF) levels of β‐endorphin in 7 Japanese patients with Joseph disease and compared them with control values. The 7 patients included 4 with type I and 3 with type II disease; their mean age was 45.7 ± 12.09 years. Diseased controls were matched in age to the patients studied. In these patients, CSF β‐endorphin level was significantly lower than in the controls (40% of normal values). An alteration in CSF β‐endorphin level may explain some of the neurological impairment found in Joseph disease.

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