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Decreased cerebrospinal fluid levels of β‐endorphin in Japanese patients with Joseph disease
Author(s) -
Matsuishi Toyojiro,
Sakai Tetsuo,
Nagamitsu Shinichiro,
Komori Hironori,
Iwashita Hiroshi,
Kato Hiroshisa
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410360317
Subject(s) - cerebrospinal fluid , beta endorphin , disease , medicine , gastroenterology , beta (programming language) , computer science , programming language
We measured the cerebrospinal fluid (CSF) levels of β‐endorphin in 7 Japanese patients with Joseph disease and compared them with control values. The 7 patients included 4 with type I and 3 with type II disease; their mean age was 45.7 ± 12.09 years. Diseased controls were matched in age to the patients studied. In these patients, CSF β‐endorphin level was significantly lower than in the controls (40% of normal values). An alteration in CSF β‐endorphin level may explain some of the neurological impairment found in Joseph disease.