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In vivo detection of myelin phospholipids in multiple sclerosis with phosphorus magnetic resonance spectroscopic imaging
Author(s) -
Husted C. A.,
Matson G. B.,
Adams D. A.,
Goodin D. S.,
Weiner M. W.
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410360219
Subject(s) - multiple sclerosis , myelin , magnetic resonance imaging , nuclear magnetic resonance , in vivo , phosphorus , nuclear magnetic resonance spectroscopy , chemistry , myelin sheath , medicine , pathology , biology , radiology , central nervous system , immunology , physics , organic chemistry , microbiology and biotechnology
The goal of this study was to investigate myelin phospholipids in vivo in multiple sclerosis lesions and normal‐appearing white matter by evaluating the spectral broad component from phosphorus 31 magnetic resonance spectroscopic imaging data. The phospholipid broad component was reduced nearly 35% ( p <001) in both lesions and in normal‐appearing white matter in multiple sclerosis subjects compared to control subjects, suggesting reduced myelin phospholipid concentration or altered relaxation times.