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Magnetic resonance spectroscopy of N ‐acetylaspartate in hypoxic–ischemic encephalopathy
Author(s) -
Graham S. H.,
Meyerhoff D. J.,
Bayne L.,
Sharp F. R.,
Weiner M. W.
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410350420
Subject(s) - magnetic resonance imaging , choline , nuclear magnetic resonance , functional magnetic resonance spectroscopy of the brain , proton magnetic resonance , forebrain , encephalopathy , nuclear magnetic resonance spectroscopy , chemistry , medicine , pathology , central nervous system , radiology , physics
Magnetic resonance imaging and water‐suppressed proton magnetic resonance spectroscopic imaging were used to study N ‐acetylaspartate and other metabolites in a patient with severe hypoxic–ischemic encephalopathy. The N ‐acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline‐containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water‐suppressed proton magnetic resonance spectroscopic imaging measurements of N ‐acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.