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Sequences of memory‐guided saccades in Parkinson's disease
Author(s) -
Vermersch AnneIsabelle,
Rivaud Sophie,
Vidailhet Marie,
Bonnet AnneMarie,
Gaymard Bertrand,
Agid Yves,
PierrotDeseilligny Charles
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410350419
Subject(s) - levodopa , parkinson's disease , neuroscience , psychology , disease , motor symptoms , audiology , physical medicine and rehabilitation , medicine
Sequences of ocular saccades were studied in 8 patients with Parkinson's disease, with (i.e., “on”) and without (i.e., “off”) levodopa treatment. The amplitude of single saccades was decreased and not improved by treatment. The chronology of saccades during sequences was impaired in patients in the “off” state, but significantly improved during the “on” period. These results are compatible with a decreased activation of the supplementary motor area, which can be reversed by levodopa.