Premium
Benign infantile familial convulsions are not an allelic form of the benign familial neonatal convulsions gene
Author(s) -
Malafosse A.,
Beck C.,
Bellet H.,
Di Capua M.,
Dulac O.,
Echenne B.,
Fusco L.,
Lucchini P.,
Ricci S.,
Sebastianelli R.,
Feingold J.,
BaldyMoulinier M.,
Vigevano F.
Publication year - 1994
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410350417
Subject(s) - medicine , allele , pediatrics , epilepsy , gene , genetics , biology , psychiatry
Abstract Benign infantile familial convulsions (BIFC) and benign familial neonatal convulsions (BFNC) are two forms of familial convulsions having an age of onset within the first year of life. The gene responsible for BFNC has been mapped to chromosome 20q in the close vicinity of D20S19 and D20S20 markers. We performed linkage analysis between BIFC and D20S19–D20S20 in eight families in order to know whether the BFNC gene is also implicated in BIFC. Several apparent obligate crossovers between affected members were detected. The data here presented demonstrate that the BFNC gene is not responsible for BIFC.