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Parvalbumin‐immunoreactive cortical neurons in Creutzfeldt‐Jakob disease
Author(s) -
Ferrer Isidro,
Casas Romi,
Rivera Rosa
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340617
Subject(s) - parvalbumin , cerebral cortex , myoclonus , neuroscience , cortical neurons , cortex (anatomy) , degenerative disease , pathology , biology , medicine , central nervous system disease
Massive abnormalities of parvalbumin‐immunoreactive cortical neurons were observed in the cerebral biopsy samples of 3 patients with Creutzfeldt‐Jakob disease. Immunoreactive cells had reduced and short, often fragmented, dendrites, and large numbers of dendritic varicosities were observed. Since parvalbumin‐immunoreactive neurons are the most important inhibitory cells in the cerebral cortex, the damage to these neurons may account, in part, for the impaired cortical function, and may play a role in the appearance of myoclonus and electroencephalographic patterns in patients with Creutzfeldt‐Jakob disease.